Actually, no. For me, I'm usually able to adjust to any type of controls of any type of game. I just have natural manual dexterity, seeing as I started playing video games at a very young age (I completely beat Turok (N64) at the age of four, okay (and I started at two)).
I don't know why, though. I guess practice does make perfect, it's just that you need a lot of practice. (I still have no idea how to use mouselook though, but I don't have a mouse anyway)