well if your build is 64-bit linux then it's incompatible but if you have 32-bit build then it's compatible (at least it works for me)
cc1: error: CPU you selected does not support x86-64 instruction set
Makefile:554: recipe for target 'pre-build' failed
make: [pre-build] Error 1 (ignored)
sdl/i_main.c:1:0: error: CPU you selected does not support x86-64 instruction set
// Emacs style mode select -*- C++ -*-
^
sdl/i_main.c:1:0: error: CPU you selected does not support x86-64 instruction set
Makefile:738: recipe for target '../objs/Linux/SDL/Release/i_main.o' failed
make: *** [../objs/Linux/SDL/Release/i_main.o] Error 1
make: Leaving directory '/home/host/build/SRB2/SRB2-SRB2_release_2.1.15/src'