In addition to the above, are you trying to run it in the software or OpenGL renderer? (If you don't know the answer off-hand, you're running software) Does switching to the other renderer (the game should have a batch file for running in OGL included) fix the issue? Is it exclusive to the DirectDraw build, or does it happen in srb2win (the SDL2 build) as well?
In fact, if it is a DD issue, just use the SDL2 builds. We only keep the DirectDraw builds around currently as a safety net in case of SDL2 issues (which I haven't encountered since 2.1.14's release), and they're likely to be phased out by the time 2.2 comes out unless we still have issues with SDL2 on some computers.