Right, I can figure out 3 key things about this.
1) you would probably go through metroid 1 and super metroid during the game, because if you look closely you will see the baby metroid die when he saves your life when mother brain fires her lazer at you
2) it will defidently have a prologue chapter to it, because there are a lot of characters that seem to know Samus that haven't been in any other games before. like the colored dude who seems to be close to her
3) If you played fusion you should know this but just in case
[spoiler:a2bba68efe]the person who says "any objections my lady?" will most likely die during the game[/spoiler:a2bba68efe]
I could be wrong about some of these though. And, i am so exited about how this game will play out, it looks fantastic.
Also team ninja making a metroid game was something I was not expecting.