I have a great glorious number.
- Any of the Night Bosses from Sonic Unleashed.
Giant Ares from God of War.
The Kraken from God of War II.
Knuckles vs. Metal Sonic from S3K.
Sonic vs. Knuckles from S3K.
Braska's Final Aeon from FFX. (Not Yu Yevon. He's a wimp.)
Most of the bosses from FFVIII (Ultimecia cheats.)
The Omega Pirate and Metroid Prime from Metroid Prime.
The Midgar Zolom from FFVII (Technically doesn't count considering you can kick his arse by disk two.)
The MZ Dragon from Sonic Megamix.
William Dresari from Mechwarrior IV Vengeance.
Casey Nolan from Mechwarrior IV Black Knight. (I loved killing that whiner.)
Chaos from FFI.
Exdeath from FFV.
Genesis from FFVII~CC~.
Any of Tsviets from FFVII~DoC~.
Gilgamesh from FFV. (If only because of Clash on the Big Bridge.)
The Giant Spider from RE1.
Del Lago from RE4.
I can think of others, but not right now.